科學家發現健康老化的基因奧秘
Scientists discover genetic secrets to aging healthily
Updated at: June 22, 2026 at 01:45 AM
在2026年6月的一項開創性研究中，研究人員解開了健康老化的新基因秘密。
In a groundbreaking study from June 2026, researchers have unlocked new genetic secrets to healthy aging.
透過研究長壽家庭，萊頓大學醫學中心(Leiden University Medical Center)的科學家發現，父母長壽的人通常會擁有更長的「健康壽命」(healthspan)——即一生中免於慢性病折磨的時期。
By studying long-lived families, scientists at Leiden University Medical Center discovered that individuals with long-lived parents often experience a significantly longer 'healthspan'—the period of life spent free from chronic disease.
一項關鍵發現是cGAS基因中的一種罕見突變。
A key discovery is a rare mutation in the cGAS gene.
通常，cGAS蛋白質在偵測到受損的DNA時會引發發炎反應。
Typically, the cGAS protein triggers inflammation when it detects damaged DNA.
然而，這種特定的突變會導致蛋白質更快降解，從而產生受控的發炎反應。
However, this specific mutation causes the protein to degrade faster, resulting in a controlled inflammatory response.
雖然APOE和FOXO3A等基因早已為人所知，但這項研究突顯了罕見的家族特異性變異如何助益於身體的恢復力。
While genes like APOE and FOXO3A are already known, this research highlights how rare, family-specific variants contribute to resilience.
至關重要的是，遺傳因素僅佔壽命變異的約25%，這意味著生活方式和環境仍然至關重要。
Crucially, genetics only accounts for about 25% of lifespan variation, meaning lifestyle and environment remain vital.
